Is the Dictionary Done For? The print edition of Merriam-Webster was once a touchstone of authority and stability. Then the internet brought about a revolution. Wars over words are inevitably culture wars, and debates over the dictionary have raged for as long as it has existed. Once, every middle-class home had a piano and a dictionary. The purpose of the piano was to be able to listen to music before phonographs were available and affordable. Later on, it was to torture young persons by insisting that they learn to do something few people do well. The purpose of the dictionary was to settle intra-family disputes over the spelling of words like "camaraderie" and "sesquipedalian," or over the correct pronunciation of "puttee." This was the state of the world not that long ago. In the late nineteen-eighties, Merriam-Webster's Collegiate Dictionary was on the best-seller list for a hundred and fifty-five consecutive weeks. Fifty-seven million copies were sold, a number believed to be second only, in this country, to sales of the Bible. There was good money in the word business.

Motivation: Standard genome-wide association studies in cancer genomics rely on statistical significance with multiple testing correction, but systematically fail in underpowered cohorts. In TCGA breast cancer (n=967, 133 deaths), low event rates (13.8%) create severe power limitations, producing false negatives for known drivers and false positives for large passenger genes. Results: We developed a five-criteria computational framework integrating causal inference (inverse probability weighting, doubly robust estimation) with orthogonal biological validation (expression, mutation patterns, literature evidence). Applied to TCGA-BRCA mortality analysis, standard Cox+FDR detected zero genes at FDR<0.05, confirming complete failure in underpowered settings. Our framework correctly identified RYR2 -- a cardiac gene with no cancer function -- as a false positive despite nominal significance (p=0.024), while identifying KMT2C as a complex candidate requiring validation despite marginal significance (p=0.047, q=0.954). Power analysis revealed median power of 15.1% across genes, with KMT2C achieving only 29.8% power (HR=1.55), explaining borderline statistical significance despite strong biological evidence. The framework distinguished true signals from artifacts through mutation pattern analysis: RYR2 showed 29.8% silent mutations (passenger signature) with no hotspots, while KMT2C showed 6.7% silent mutations with 31.4% truncating variants (driver signature). This multi-evidence approach provides a template for analyzing underpowered cohorts, prioritizing biological interpretability over purely statistical significance. Availability: All code and analysis pipelines available at github.com/akarlaraytu/causal-inference-for-cancer-genomics

The operation of humanoid robotics is an essential field of research with many practical and competitive applications. Many of these systems, however, do not invest heavily in developing a non-expert-centered graphical user interface (GUI) for operation. The focus of this research is to develop a scalable GUI that is tailored to be simple and intuitive so non-expert operators can control the robot through a FIRA-regulated obstacle course. Using common practices from user interface development (UI) and understanding concepts described in human-robot interaction (HRI) and other related concepts, we will develop a new interface with the goal of a non-expert teleoperation system.

Temporal reasoning about historical events is a critical skill for NLP tasks like event extraction, historical entity linking, temporal question answering, timeline summarization, temporal event clustering and temporal natural language inference. Yet efforts on benchmarking temporal reasoning capabilities of large language models (LLMs) are rather limited. Existing temporal reasoning datasets are limited in scale, lack multilingual coverage and focus more on contemporary events. To address these limitations, we present HistoryBank, a multilingual database of 10M+ historical events extracted from Wikipedia timeline pages and article infoboxes. Our database provides unprecedented coverage in both historical depth and linguistic breadth with 10 languages. Additionally, we construct a comprehensive question answering benchmark for temporal reasoning across all languages. This benchmark covers a diverse set of 6 temporal QA reasoning tasks, and we evaluate a suite of popular language models (LLaMA-3-8B, Mistral-7B, Gemma-2-9b, Qwen3-8B, GPT4o) to assess their performance on these tasks. As expected GPT4o performs best across all answer types and languages; Gemma-2 outperforms the other small language models. Our work aims to provide a comprehensive resource for advancing multilingual and temporally-aware natural language understanding of historical events. To facilitate further research, we will make our code and datasets publicly available upon acceptance of this paper.

Motivation. Understanding the pan-cancer mutational landscape offers critical insights into the molecular mechanisms underlying tumorigenesis. While patient-level machine learning techniques have been widely employed to identify tumor subtypes, cohort-level clustering, where entire cancer types are grouped based on shared molecular features, has largely relied on classical statistical methods. Results. In this study, we introduce a novel unsupervised contrastive learning framework to cluster 43 cancer types based on coding mutation data derived from the COSMIC database. For each cancer type, we construct two complementary mutation signatures: a gene-level profile capturing nucleotide substitution patterns across the most frequently mutated genes, and a chromosome-level profile representing normalized substitution frequencies across chromosomes. These dual views are encoded using TabNet encoders and optimized via a multi-scale contrastive learning objective (NT-Xent loss) to learn unified cancer-type embeddings. We demonstrate that the resulting latent representations yield biologically meaningful clusters of cancer types, aligning with known mutational processes and tissue origins. Our work represents the first application of contrastive learning to cohort-level cancer clustering, offering a scalable and interpretable framework for mutation-driven cancer subtyping.

Mixed modality search -- retrieving information across a heterogeneous corpus composed of images, texts, and multimodal documents -- is an important yet underexplored real-world application. In this work, we investigate how contrastive vision-language models, such as CLIP, perform on the mixed modality search task. Our analysis reveals a critical limitation: these models exhibit a pronounced modality gap in the embedding space, where image and text embeddings form distinct clusters, leading to intra-modal ranking bias and inter-modal fusion failure. To address this issue, we propose GR-CLIP, a lightweight post-hoc calibration method that removes the modality gap in CLIP's embedding space. Evaluated on MixBench -- the first benchmark specifically designed for mixed modality search -- GR-CLIP improves NDCG@10 by up to 26 percentage points over CLIP, surpasses recent vision-language generative embedding models by 4 percentage points, while using 75x less compute.

In this work, we propose Perspective Reasoning for Integrated Synthesis and Mediation (PRISM), a multiple-perspective framework for addressing persistent challenges in AI alignment such as conflicting human values and specification gaming. Grounded in cognitive science and moral psychology, PRISM organizes moral concerns into seven "basis worldviews", each hypothesized to capture a distinct dimension of human moral cognition, ranging from survival-focused reflexes through higher-order integrative perspectives. It then applies a Pareto-inspired optimization scheme to reconcile competing priorities without reducing them to a single metric. Under the assumption of reliable context validation for robust use, the framework follows a structured workflow that elicits viewpoint-specific responses, synthesizes them into a balanced outcome, and mediates remaining conflicts in a transparent and iterative manner. By referencing layered approaches to moral cognition from cognitive science, moral psychology, and neuroscience, PRISM clarifies how different moral drives interact and systematically documents and mediates ethical tradeoffs. We illustrate its efficacy through real outputs produced by a working prototype, applying PRISM to classic alignment problems in domains such as public health policy, workplace automation, and education. By anchoring AI deliberation in these human vantage points, PRISM aims to bound interpretive leaps that might otherwise drift into non-human or machine-centric territory. We briefly outline future directions, including real-world deployments and formal verifications, while maintaining the core focus on multi-perspective synthesis and conflict mediation.

Concise and meaningful method names are crucial for program comprehension and maintenance. However, method names may become inconsistent with their corresponding implementations, causing confusion and errors. Several deep learning (DL)-based approaches have been proposed to identify such inconsistencies, with initial evaluations showing promising results. However, these evaluations typically use a balanced dataset, where the number of inconsistent and consistent names are equal. This setup, along with flawed dataset construction, leads to false positives, making reported performance less reliable in real-world scenarios, where most method names are consistent. In this paper, we present an empirical study that evaluates state-of-the-art DL-based methods for identifying inconsistent method names. We create a new benchmark by combining automatic identification from commit histories and manual developer inspections, reducing false positives. We evaluate five representative DL approaches (one retrieval-based and four generation-based) on this benchmark. Our results show that performance drops substantially when moving from the balanced dataset to the new benchmark. We further conduct quantitative and qualitative analyses to understand the strengths and weaknesses of the approaches. Retrieval-based methods perform well on simple methods and those with popular name sub-tokens but fail due to inefficient representation techniques. Generation-based methods struggle with inaccurate similarity calculations and immature name generation. Based on these findings, we propose improvements using contrastive learning and large language models (LLMs). Our study suggests that significant improvements are needed before these DL approaches can be effectively applied to real-world software systems.

Radio remains a pervasive medium for mass information dissemination, with AM/FM stations reaching more Americans than either smartphone-based social networking or live television. Increasingly, radio broadcasts are also streamed online and accessed over the Internet. We present WavePulse, a framework that records, documents, and analyzes radio content in real-time. While our framework is generally applicable, we showcase the efficacy of WavePulse in a collaborative project with a team of political scientists focusing on the 2024 Presidential Elections. We use WavePulse to monitor livestreams of 396 news radio stations over a period of three months, processing close to 500,000 hours of audio streams. These streams were converted into time-stamped, diarized transcripts and analyzed to track answer key political science questions at both the national and state levels. Our analysis revealed how local issues interacted with national trends, providing insights into information flow. Our results demonstrate WavePulse's efficacy in capturing and analyzing content from radio livestreams sourced from the Web. Code and dataset can be accessed at \url{https://wave-pulse.io}.

Visual communication, dating back to prehistoric cave paintings, is the use of visual elements to convey ideas and information. In today's visually saturated world, effective design demands an understanding of graphic design principles, visual storytelling, human psychology, and the ability to distill complex information into clear visuals. This dissertation explores how recent advancements in vision-language models (VLMs) can be leveraged to automate the creation of effective visual communication designs. Although generative models have made great progress in generating images from text, they still struggle to simplify complex ideas into clear, abstract visuals and are constrained by pixel-based outputs, which lack flexibility for many design tasks. To address these challenges, we constrain the models' operational space and introduce task-specific regularizations. We explore various aspects of visual communication, namely, sketches and visual abstraction, typography, animation, and visual inspiration.